Intramuscular Diphenhydramine Does Not Affect Acute Doxorubicin Infusion-Related Arrhythmia Number or Severity in a Prospective Crossover Study in Canine Lymphoma: A Pilot Study
Background: Doxorubicin (DOX) is one of the most effective chemotherapeutics for canine high-grade lymphoma.In addition to dose-dependent chronic cardiotoxicity, DOX can trigger acute cardiac arrhythmias during drug infusion.Diphenhydramine premedication is commonly used, as histamine release is a proposed mechanism for DOX-associated arrhythmogene